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Seminar 5: Environmental Genomics – Pathogen Surveillance, Tracing the Source of Human Cases and Health Compliance

“Environmental Genomics – Pathogen Surveillance, Tracing the Source of Human Cases and Health Compliance”
by: Dr. Shaharuddin A.
DATE:  Wednesday, 23rd January, 2013
TIME: 3-4pm

ABSTRACT

Recent advances in human and molecular genetics provide an unparalleled opportunity to understand how genes and genetic changes interact with environmental stimuli to either preserve health or cause disease. The fields of environmental genetics and environmental genomics have enormous potential to affect our ability to accurately assess the risk of developing disease and to identify and understand basic pathogenic mechanisms. The development of disease in humans due to environmental factors and otherwise is complex. As environmental exposures substantially contribute to the etiology of many common complex human diseases, environmental health scientists have a unique opportunity to focus on the interface between environmental exposures, basic biology/genetics, technology and business on vulnerable populations and the common diseases that limit our longevity. In this lecture, “genomic” is used broadly to include bioinformatics, proteomics, and other “omic” sciences. The research activities thus far (2004-2012) has facilitated interactions and collaborations between members now using genomic-based technology worldwide and others who have active programs in ecology or the environmental sciences. There are synergies and interactions among scientists who might not otherwise collaborate.  The goal of this presentation is to show how the concentrations of bacterial pathogens in the environment can be determined through utilizing biotechnology techniques and methods as opposed to culturing.

This presentation will focus on:

  • Biotechnology (Malaysia’s Focus Areas) and its Application in the Poultry Industry.
  • Pathogen Detection, Identification and Surveillance: Poultry, Food Industry and Human Health.
  • The Role of the University (Entrepreneural-Technopreneural Roadmap)
  • Poultry environmental pathogen genomics and its relevance in tracing the source of human cases associated with:
    • Campylobacter jejuni
    • Bacteroides fragilis
    • Escherichia coli 0157:H7
    • Bacteroides
    • Bacteroides acidofaciens

These will be discussed with respect to the role of real-time quantitative polymerase chain reaction, the effect on human health studies and the possibility for the development of biosensors applicable for the detection of food pathogens.

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